The unfolded protein response (UPR) is a pivotal mechanism to mitigate protein homeostasis through transcriptional or translational control. On the other hand, since dysregulation of UPR has been ...

BUFFALO, N.Y. — Foxglove plants, found in many gardens, are known for the showers of bell-shaped flowers they produce. But plants belonging to this genus, Digitalis, also harbor a less visible asset: ...

Several drugs now being used to treat heart failure and atrial arrhythmia also show promise as DNA disruptors in cancer cells and could be readily repurposed as anticancer agents, according to a new ...

Digitalis has been used to treat heart failure for more than 200 years. The drug digitoxin also belongs to this group of active ingredients known as cardiac glycosides. Non-antibiotic drugs can alter ...

To understand better and more deeply appreciate the development of knowledge in this field, it is desirable to begin with the simpler aspects of the action of these glycosides and then to proceed to ...

Foxglove has digoxin that has a powerful effect on the heart. Foxglove, scientifically known as Digitalis, is a distinctive flowering plant renowned for its elegant, tubular blossoms and rich history ...

In the present study, Dr. Hidetoshi Hayashi (Professor, Nagoya City University) and collaborators screened small-molecule compounds that suppress UPR, using Myanmar wild plant extracts library. The ...