Those hoping to uncover new science may feel disheartened if they struggle with inadequate tools and doubt that more capable tools are within reach. Until recently, such was the case in proteomics.

Flow cytometry, invented in the 1950s, uses antibodies linked to fluorescent probes to detect cell surface and intracellular proteins. Although able to achieve single-cell sensitivity, the method is ...

Spatial proteomics is the study of the spatial distribution of the proteins within cells and tissues. The subcellular localization of proteins is intrinsic to cellular function, making spatial ...

For biologists, seeing is believing. But sometimes biologists have a hard time seeing. One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of ...

Advances in proteomics and mass spectrometry enable the study of limited cell populations such as performing mouse models. Low-protein load studies often require two steps to perform differential ...

Effective protein characterization depends on the precise isolation and fragmentation of peptide ions within the mass spectrometer, typically coupled with liquid chromatography (LC-MS/MS). In a ...