Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During ...

T cells dynamically adapt to signals in the TME, transitioning between effector, exhausted, and regulatory states. Cellular interactions, metabolic stress, and physical barriers (e.g., ECM) shape ...

Cancer cells don’t just shape shift. They state shift. That is, they can embody different cell states, or types, that possess different degrees of plasticity or hereditability. If cancer cells become ...

A recent study suggests that the SIX2 protein may be a possible factor underlying increased plasticity of prostate cancer cells and treatment resistance. Treatment resistance caused by cancer cell ...

Scientists disclose how mitochondria control tissue rejuvenation and synaptic plasticity in the adult mouse brain. Nerve cells (neurons) are amongst the most complex cell types in our body. They ...

A mathematical model describes tumor dynamics where the tumor comprises drug-sensitive cancer cells (S), -resistant cancer cells (R), and plastic cancer cells (P). The model proposes evolutionary ...

Cancer plasticity refers to the remarkable ability of cancer cells to alter their identity, function, and behavior in response to environmental stressors or therapeutic pressures. This dynamic trait ...

After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of "good" microbes in the gut is linked to ...