This is a preview. Log in through your library . Abstract The coding region of the hamster desmin gene was fused to the 5′ flanking sequences of the hamster vimentin gene and introduced into the germ ...

Desminopathies are a therapeutic challenge as there are over 130 different mutations in the human desmin gene resulting in myopathy and/or cardiomyopathy. In this issue, a gene therapeutic approach is ...

A missense mutation in the αB-crystallin (CryAB) gene triggers a severe form of desmin-related cardiomyopathy (DRCM) characterized by accumulation of misfolded proteins. We hypothesized that autophagy ...