In recent years, the issue of potential drug-drug interactions (DDI) occurring when pharmaceuticals are co-administered has become a subject of increasing recognition. The high frequency of DDIs is ...

In the past decade, the number of antibiotics to which bacteria have developed resistance has increased considerably. As a consequence, some agents are no longer useful for the treatment of infections ...

Researchers have used a combination of genetic manipulation and protein structural analysis to determine how the position of 'bulky' amino acids influences the ability of efflux pump inhibitors to ...

image: The inhibitor-binding site of the wild-type MexB pump. (a) The crystal structure of the inhibitor ABI-PP bound to the MexB trimer. Three MexB monomers are shown in green, blue, and red, ...