Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found ...

Targeted therapies and immunotherapies offer new treatment options for more types of cancer, but these drugs are less helpful when tumors produce multiple copies of a gene. This gene amplification ...

DECEMBER 23, 2020, NEW YORK - Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, ...

Many types of cells have to be replenished throughout our lives, and healthy cells can divide into two new cells to replace ones that are damaged or worn out. Cell division has to be carefully ...

SAN DIEGO--(BUSINESS WIRE)--Boundless Bio, a next-generation precision oncology company developing innovative therapeutics directed against extrachromosomal DNA (ecDNA) in aggressive cancers, today ...

SAN DIEGO--(BUSINESS WIRE)--Boundless Bio, a clinical stage next-generation precision oncology company developing innovative therapeutics directed against extrachromosomal DNA (ecDNA) in oncogene ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

The word “chromothripsis” literally means “chromosome shattering.” Chromosomes that undergo chromothripsis first fragment into many pieces and then get stitched back together in a random order by DNA ...

Scientists describe how a phenomenon known as 'chromothripsis' breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth. Cancer is one of the world's greatest ...

STARMAP (Study Treating Acquired Resistance: MAPK Amplifications) is a first-in-human, 3-part, Phase 1/2 study of BBI-825 as a single agent and in combination with select targeted cancer therapies BBI ...