Aggressive cancer growth and alterations in gene activity without changes in DNA sequence (epigenetics) are associated with mutant p53 proteins, according to new research from the Perelman School of ...

Bottom Line: Researchers from Memorial Sloan Kettering Cancer Center (MSK) have identified, for the first time, an epigenetic mechanism promoting breast cancer. The team found that inhibition of the ...

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, ...

Epigenetics play a significant role in cancer onset and spread, and scientists explore epigenetic regulators for their roles in carcinogenesis. In this webinar brought to you by The Scientist, Özgen ...

(A) DNA methylation is maintained by DNMT1 on hemimethylated DNA after replication, while DNMT3A/3B catalyse de novo methylation on unmethylated DNA. In mammals, this modification is primarily found ...

Researchers have revealed the mechanism of the drug valemetostat shown to be effective in treating certain types of cancer by targeting a protein modification (histone methylation) silencing the ...

Dave Lahr, PhD, is currently leading the computational biology group at Foghorn Therapeutics, a biotech startup focused on treating diseases by correcting abnormal gene expression. In the early days ...

Researchers have discovered a mechanism behind the yo-yo effect: fat cells have a memory that is based on epigenetics. Researchers at ETH Zurich have discovered a mechanism behind the yo-yo effect: ...

A decline in the expression of the epigenetic regulator Setd8 in neural stem cells (NSCs) during early adulthood leads to chromatin condensation and reduced gene expression, suppressing NSC ...