Extrachromosomal circular DNA (ecDNA) represents a distinct genomic entity that exists independent of the primary chromosomal structure. In cancer, ecDNA is recognised as a potent driver of oncogene ...

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA - loops of DNA found outside of regular chromosomes - are twice as ...

This is a preview. Log in through your library . Abstract Extrachromosomal circular DNA (eccDNA) originates from linear chromosomal DNA in various human tissues under physiological and disease ...

A method for parallel sequencing of single-cell extrachromosomal circular DNA (ecDNA) and full-length mRNA transcriptomes has enabled new insights into the roles of ecDNA in cancer progression, ...

Lukas Chavez uses multiomic techniques to study how extrachromosomal DNA (ecDNA) contributes to tumor heterogeneity and gene expression changes in medulloblastoma. In the 1960s, researchers in England ...

The incidence of Human Papillomavirus (HPV)-associated oropharyngeal cancers — tumors of the back of the mouth and throat — is rising. If caught early, most of these cancers have a high survival rate, ...

Neuroblastoma can be a particularly insidious cancer. In about half of all cases, tumors regress, even without therapy. In the other half, tumors grow very quickly. These tumors often respond well to ...

Most of an animal cell’s DNA is stored in its nucleus, packaged into chromosomes that help maintain order. But cancer cells often carry another type of DNA: molecules separate from the rest of the ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

Scientists in Tokyo have uncovered “Inocles,” massive strands of extrachromosomal DNA hidden inside bacteria in human mouths. These giants, overlooked by traditional sequencing, could explain how oral ...