GPCRs are involved in various physiological processes, such as the regulation of behavior, mood, and immune system activity. GPCRs represent one of the most important targets in drug discovery; ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). GPCRs are indispensable for ...

Researchers at University of California San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse ...

A group of researchers has identified the cause of a 'short-circuit' in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases and could lead to development ...

G protein–coupled receptors (GPCRs) initiate signaling cascades while ensconced in the cell membrane. At least, that’s where GPCRs are usually found. But some GPCRs ride endosomes into the cell’s ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 28 (July 13, 2021), pp. 1-10 (10 pages) The evolutionary expansion of G protein-coupled receptors (GPCRs) ...

Researchers at University of California San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse ...

Single-cell proteogenomic analysis defined the lymphoma microenvironment as immune-inflamed, -deficient, and desert, in association with different setpoints of cancer-immunity cycle. EBV interacted ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...