Researchers in Germany have discovered previously unknown subunits of the GABAB receptors in the central nervous system. GABAB receptors are transmembrane proteins in nerve cells which are of ...

GABA-A receptors mediating synaptic or extrasynaptic transmission are molecularly and functionally distinct, and glial cells are known to express a plethora of GABA-A subunits. Here we demonstrate ...

Using cryo-electron microscopy, scientists have gotten their first atomic snapshot of a human GABA A receptor. This inhibitory channel is the target of a range of anesthetic, anxiolytic, and ...

A new way to study the role of a critical neurotransmitter in disorders such as epilepsy, anxiety, insomnia, depression, schizophrenia, and alcoholism has been developed. The new method involves ...

Despite the importance of γ-aminobutyric acid type A (GABA A) receptors as drug targets for a wide range of health conditions, a crystal structure has never been determined—until now. Paul S. Miller ...

A healthy brain balances “activate” and “inhibit” signaling in its neural microcircuitry, with the inhibitory signaling often provided by cell receptors for the neurotransmitter GABA. Unexpected ...

The major inhibitory amino acid transmitter within the mammalian central nervous system (CNS) is GABA. Largely all of the brain’s neurons respond to GABA, while approximately 20% use it as their ...

Research led by Jia Zhou in the Hibbs Lab at UC San Diego has mapped the structures of human brain receptors for the neurotransmitter GABA. The team obtained samples from epilepsy patients undergoing ...

Certain proteins found in the human brain have long been known to be critical to controlling how brain cells communicate with each other. So-called GABA A receptors are proteins that control the flow ...