Cellular parasites have evolved clever anti-apoptosis strategies to avoid being killed by CTLs. However, CTL release of granzyme A inactivates a key repair enzyme, Ape1, ensuring death of infected ...

Granzyme K (GzmK), a family of granzymes implicated in age-associated inflammatory disease, plays a key role in driving chronic inflammation by causing cell death. Despite its significant impact on ...

Gold nanoparticles that cluster in response to T cell enzymes can predict cancer immunotherapy success days before tumors ...

Harvard Medical School scientists have identified a key protein in the human immune system that drives inflammatory and autoimmune conditions when it turns against the body. The protein, Granzyme K, ...

Visual Abstract. Active bowel inflammation disrupts the bowel cell lining, which causes the inflammatory T cells to secrete Granzyme B into the extracellular space, progressively accentuating the ...

Please provide your email address to receive an email when new articles are posted on . A protein known as granzyme K was recently shown to be a driver of inflammation by activating the complement ...

SUDBURY, Mass.--(BUSINESS WIRE)--CytoSite Bio, a company developing precision imaging products that determine patient response to immuno-oncology therapy today shared new data at the Radiological ...

Researchers at the University of British Columbia (UBC) and Vancouver Coastal Health Research Institute (VCHRI) have identified a key enzyme that contributes to eczema, which may lead to better ...

A Cytosite Biopharma Inc. patent describes prodrugs of granzyme B-targeting compounds reported to be useful as granzyme B-imaging agents for the diagnosis of cancer.

A groundbreaking study published in Nature on Jan 16 uncovers a novel subset of memory CD8+ T cells, which are capable of "remembering" an antigen upon subsequent encounters, leading to a faster and ...

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases. Study: ...