A novel genome editing technique, NICER, is based on the creation of multiple nicks in single DNA strands by nickase. The method can correct heterozygous mutations using two mechanisms: multiple nicks ...

Eukaryotic genomes are organized into a finite number of linear double-stranded DNA molecules (chromosomes) ranging in length from kilobases to gigabases and containing unique and nonunique segments.

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease. However, the CRISPR/Cas9 method ...

Homozygous, or homozygosity, refers to the inheritance of genes from each biological parent. Inheriting faulty genes from both parents can cause a person to develop the associated condition. Genetic ...