A new study, led by Professors Mashaghi and Clevers from Leiden University and Hubrecht Institute in the Netherlands, has introduced a novel approach using intestinal organoids to uncover the ...

Tuft cells are present throughout the intestinal tract as well as in many organs. Studies in mice have shown that when tuft cells sense the presence of pathogens, they signal to immune cells and to ...

Attrition in the therapeutic pipeline can often be associated with the lack of translational efficacy from the pre-clinical phase to the clinic. Organoids demonstrate the significant potential to ...

The trillions of microbes in our gastrointestinal tract, known as the gut microbiome, are crucial to the body; the gut microbiome aids in digestion, nutrient absorption, and influences our health in ...

Ebola virus and Marburg virus are both highly contagious filoviruses and are among the most lethal viruses known. Patient deaths are often a consequence of gastrointestinal damage leading to diarrhea ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Organoids are three-dimensional, miniaturized, and simplified versions of organs produced in vitro from stem cells or organ-specific progenitor cells. They recapitulate key structural and functional ...

Plastics pervade every aspect of the human life, being present in packaging and household goods, agricultural, food and medical products. Their resistance to (bio)degradation has resulted in the ...