Translation efficiency and poly (A) tail length are not linearly correlated and only coupled in limited range, report scientists. This research is, 'helping to build the foundation for further work ...

For mRNA-based therapeutics and vaccines, poly(A) tail length is a critical quality attribute (CQA) due to its direct impact on mRNA stability and translation efficiency. Single-nucleotide resolution ...

Protein synthesis in the heart is a dynamic process, characterized by low synthesis rates in the adult heart that can increase substantially in periods of hypertrophy; however the regulatory ...

Before mRNA can be used by ribosomes as a guide to build proteins, it has to undergo a series of processing steps. This includes getting a series of adenine (A) nucleotides added by poly(A) polymerase ...