In recent years, the field of cancer metabolism has found that cancer cells can manipulate the PKM2 enzyme to grow and thrive. Now a new study finds that cancers also use PKM2 to withstand oxidative ...

Tumour cells exclusively express the embryonic M2 isoform of pyruvate kinase (PKM2). PKM2 expression levels have been correlated with the effect of platinum compounds in cancer cell lines and ...

PKM2 acts like a switch for cellular energy, directly determining whether cancer cells can rapidly generate energy and biosynthetic precursors to support their continued growth. Using a driving ...

Polymorphisms of thymidylate synthase as prognostic factor in rectal cancer. Background: Tumour cells have been shown to express exclusively the embryonic M2 isoform of pyruvate kinase (PKM2), which ...

Phase II study of ganetespib, an hsp-90 inhibitor, in patients with refractory metastatic colorectal cancer. Background: Tumor cells have been shown to express exclusively the embryonic M2 isoform of ...

This new article publication from Acta Pharmaceutica Sinica B, discusses targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by ...

Nearly 80 years ago, scientist Otto Warburg observed that cancer cells perform energy metabolism in a way that is different from normal adult cells, but it has not been known exactly how tumor cells ...

Sitryx Therapeutics Ltd. has identified compounds acting as pyruvate kinase M2 (PKM2) and/or PKLR activators reported to be useful for the treatment of cancer, obesity, inflammation, diabetes and ...

BOSTON – Nearly 80 years ago, scientist Otto Warburg observed that cancer cells perform energy metabolism in a way that is different from normal adult cells. Many decades later, this observation was ...

A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases. The work ...