A new research paper titled "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span" has been published in Aging. The decrease in the podocytes' lifespan and health span ...

Unlike other human stem cells, Induced pluripotent stem cells (iPS cells) can be produced directly from adult cells. Now, researchers have shown that human kidney podocytes produced from iPS cells via ...

End-stage kidney disease often begins with injury to podocytes. These highly specialized cells are a critical part of the glomeruli, clusters of capillaries that serve as the filtration units in our ...

A single podocyte was reconstructed in three dimensions based on serial glomerular section images obtained by array tomography. The three-dimensional reconstruction enabled quantitative volume ...

BUFFALO, N.Y. — In the early stages of kidney disease, a specialized type of kidney cell called the podocyte undergoes damaging changes in both its structure and function. Those changes are key ...

Although the pathophysiology of mesangial cells has long been considered to be the major factor in the development of glomerulosclerosis in type 1 or type 2 diabetes, more recent evidence suggests ...

Human stem cells are of great interest in the fields of regenerative medicine and medical research because they reproduce indefinitely and can differentiate into every other cell type found in the ...

Podocytes are a terminally differentiated cell type located in the glomerulus. Podocyte damage and the subsequent dysregulation of podocyte proteins have been implicated in various kidney disorders.

A newly-established protocol offers hope for kidney disease modeling, drug discovery, and potential cell therapies. Previous work from the Wyss Institute at Harvard University established a protocol ...