One of the main goals of proteomics is to unravel the many modifications important for biological activity. Post-translational modifications (PTMs) extend the range of protein function by attaching it ...

Chief among these is accurately and reproducibly mimicking natural post-translational modifications. Identifying and characterizing such modifications impact half-life, quality, cost, and potential ...

Aberrant Glycosylation Drives Kidney Disease Pathogenesis. This schematic illustrates how abnormal glycosylation contributes to diverse kidney diseases: (A) galactose-deficient IgA1 in ...

Kidney diseases affect nearly 700 million people worldwide and are a growing cause of mortality and health care costs. Chronic kidney disease (CKD) alone contributes to over 1.2 million deaths ...

Please provide your email address to receive an email when new articles are posted on . As highlighted in recent advances in rheumatoid arthritis pathogenesis, researchers’ understanding of the ...

Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.

The host cell system is a critical determinant of recombinant protein quality and yield, with direct influence on protein folding and post-translational modification factors that shape the ...

Researchers from the National University of Singapore (NUS) have developed a new biomimetic concept to convert naturally occurring sugars into diverse classes of stable glycosides and glycoproteins ...