The homozygous mutation (677TT) in the methylenetetrahydrofolate reductase (MTHFR) gene reduces enzyme activity and alters cellular folate composition. Previous epidemiological studies reported a ...
Plasma vitamin B12 and folate concentrations were determined by radio-dilution isotope assay (simulTRAC-SNB, ICN Pharmaceuticals, Costa Mesa, CA) (6). HCY concentration was assessed by fluorescent ...
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