Sensory nerve action potential amplitudes decreased as patients aged in a cohort of spinal muscular atrophy (SMA) type 1 patients compared with a healthy, age-matched control group. Spinal muscular ...

"Alterations in axonal membrane and channel function occur early in the disease course, prior to discernable large fibre involvement, and has the potential to be used as an early biomarker of ...

Experiments in animal models of chronic distal symmetrical sensory peripheral neuropathies have demonstrated mitochondrial dysfunction in primary afferent sensory neurons The mitochondrial dysfunction ...

Giant axonal neuropathy (GAN) is a rare, autosomal recessive neurodegenerative disorder, characterized by a spectrum of symptoms and a challenging prognosis. Now, a study published recently in the New ...

Neurologic paraneoplastic manifestations are rarely described in children with acute lymphoblastic leukemia (ALL). Most of these appear during the course of treatment. We describe a child who had a ...

Small fiber sensory neuropathy is a neuromuscular disorder that affects millions of people. It can be caused by various conditions, such as diabetes or prediabetes. It can also occur on its own. Main ...

An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit ...

A motor disorder at the admission was referred in 94 patients, with a variable degree. By classifying them according to the GBS disability score, 55% retained the ability to walk (grades 1, 2 and 3), ...

Laryngeal sensory neuropathy affects the nerves in the larynx, or the voice box. This area of the throat contains the vocal cords and has a role in breathing, swallowing, and talking. Laryngeal ...

A 56-year-old woman presents to the hospital complaining of generalized weakness that has been progressing for the past month. Her initial symptoms involved numbness and weakness in her legs and lower ...