When and how the spliceosome assembles on its substrates in living yeast cells has been unclear. It is now evident that the 'when' is during transcription; the 'how' remains debatable. Current models ...
A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...
A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...
After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...
A conserved region of U6 small nuclear RNA has been implicated in binding an essential metal ion. Is this a glimpse of the spliceosome's catalytic core? Identifying divalent metal ion binding sites in ...
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The ...
To sustain life, processes in biological cells have to be strictly controlled both in time and in space. Researchers have elucidated a previously unknown mechanism that regulates one of the essential ...
WHEN WE HUMANS got a first glimpse of our genome, we had good reason to question our biological complexity. Many scientists predicted we would possess some 100,000-plus genes, but sequencers finally ...
Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA—a prerequisite for protein synthesis in the cell. The poorly ...
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