Figure 1: Dynamics of tRNA modifications as BCG enter and exit hypoxic non-replicating persistence. Figure 3: The choice between codons Thr ACG and Thr ACC influences protein up- or downregulation in ...

During translation, the ribosome progressively coordinates the dynamic interplay of tRNA and protein factors to decipher individual codons of an mRNA molecule and synthesize protein. The ribosome ...

For disorders driven by a known genetic component, research understandably focuses on developing a drug targeting that genetic signature. When that works, the outcome benefits patients but the end ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

When Daniel Fischer cofounded Tevard Biosciences in 2017, he wasn’t trying to bet on the next hot RNA technology. His interest was more personal. His daughter Natasha has Dravet syndrome, a rare form ...

Alltrna is advancing a new class of genetic medicines based on the power of tRNA biology to universally treat Stop Codon Disease, which encompasses thousands of genetic diseases caused by a premature ...