Granzyme Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death (apoptosis) in the target …

Granzymes belong to the serine-protease family, and five human members have been identified: granzyme A (GA), granzyme B (GB), granzyme H (GH), granzyme M (GM) and granzyme K …

Jun 11, 2025 · While there are several types of granzymes, such as Granzyme A, B, H, K, and M, Granzyme B is one of the most extensively studied for its ability to induce cell death. …

Granzyme refers to small serine proteases, approximately 32 kDa in size, stored in the cytoplasmic secretory vesicles of cytotoxic lymphocytes and natural killer cells, which are …

Apr 30, 2024 · In this Review, the authors discuss granzyme biology with an emphasis on its involvement in rheumatic disease pathology.

Apr 5, 2024 · Granzymes belong to the serine-protease family, and five human members have been identified: granzyme A (GA), granzyme B (GB), granzyme H (GH), granzyme M (GM) …

Granzyme A contains certain chemicals that allow it to cause proliferation in B cells to reduce the chance of cancer growth and formation. Test on mice have shown that granzyme A and B …

Dec 4, 2025 · Granzyme A, the second most abundant granzyme, works through a distinct, caspase-independent pathway to induce cell death. It traffics to the mitochondria where it …

Apr 5, 2024 · Additional roles have been identified in the extracellular milieu, following granzyme escape from the immunological synapse or their release by specific cell types.

Feb 6, 2022 · In this review, we describe what is currently known about granzyme structure, processing, and granzyme-induced cell death in the context of cancer and in some other …