What is pernicious anemia? Pernicious (per-nish-uhs) anemia, one of the causes of vitamin B12 deficiency, is an autoimmune condition that prevents your body from absorbing vitamin B12. …

Mar 31, 2024 · An autoimmune condition in which the body's immune system attacks the actual intrinsic factor protein or the cells in the lining of your stomach that make it. In rare cases, …

Intrinsic factor (IF), also known as cobalamin binding intrinsic factor, [5] or gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of …

The inability to make intrinsic factor may be the result of several factors, such as chronic gastritis, gastrectomy (removal of all or part of the stomach), or an autoimmune condition (the body …

Mar 24, 2022 · Lack of intrinsic factor: Intrinsic factor is a protein made in the stomach, which helps the body absorb vitamin B12. People who have pernicious anemia do not produce …

Mar 24, 2023 · Absence of intrinsic factor, also called pernicious anemia — Intrinsic factor is a protein secreted by cells of the stomach lining. Intrinsic factor attaches to vitamin B 12 and …

Apr 29, 2005 · Katz et al. (1974) described a type of congenital intrinsic factor defect in which intrinsic factor had normal cobalamin-binding ability and immunoreactivity but showed very …

Feb 21, 2019 · Intrinsic Factor Deficiency Disorder is diagnosed on the basis of the following information: Many clinical conditions may have similar signs and symptoms. Your healthcare …

Intrinsic factor deficiency is caused by changes (mutations) in the GIF gene and is inherited in an autosomal recessive manner. [2][3] Treatment generally consists of vitamin B12 injections.

Congenital intrinsic factor deficiency (IFD) is a rare disorder of vitamin B12 (cobalamin) absorption that is characterized by megaloblastic anemia and neurological abnormalities.