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0:52
YouTube
The Krusty Lab
The paradox of blocking BRAF #cancer #oncology #science
Why does BRAF inhibition sometimes fail? Understand the mechanism behind vemurafenib resistance. This breakdown explains how blocking BRAF can unintentionally cause ERK output to drop, lifting the suppression on RAS signalling. We trace how this network rerouting leads to RAS-driven tumour growth in patients undergoing targeted therapy ...
14 views
3 weeks ago
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l've been quiet for a few months. This is why. In May, I found a lump in my neck. No pain, no symptoms, I felt completely fine. It turned out to be stage 4 bowel cancer, already in my liver, my abdomen and my chest. Since then: emergency surgery, an ileostomy, four procedures to unblock my bile ducts, sepsis, and five weeks in a hospital bed. Genetic testing has now found a mutation in my tumour called BRAF V600E. It's aggressive, and it resists standard chemotherapy. But there's a targeted trea
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